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January 1985

DNA Flow Cytometry of Thyroid Neoplasms

Author Affiliations

From the Departments of Pathology (Drs Kraemer, Srigley, Batsakis, and Silva) and Head and Neck Surgery (Dr Goepfert), University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Texas Medical Center, Houston. Dr Kraemer is now with St John-Mercy Medical Center, St Louis. Dr Srigley is now with Sunnybrook Medical Center, University of Toronto.

Arch Otolaryngol. 1985;111(1):34-38. doi:10.1001/archotol.1985.00800030068008

• Mechanically dispersed cell suspensions from 23 thyroid lesions were studied by acridine orange flow cytometry. Eight of 14 carcinomas (three papillary, two medullary, two Hürthle cell, and one follicular) manifested abnormal DNA indices ranging from 0.6 to 2.0. Six carcinomas (four papillary and two medullary) were diploid. Four patients having papillary carcinomas with diploid DNA content were young women whose clinical course of disease was indolent. Three papillary carcinomas with abnormal DNA content were found in older men with clinically aggressive disease. One benign adenomatoid nodule displayed a small population with a low-degree hyperdiploid stemline (DNA index = 1.1) with low proliferative activity. Differentiation between clinically indolent and aggressive carcinomas may be possible by nuclear DNA determination, but further work is needed to determine the importance of proliferative activity in thyroid carcinoma.

(Arch Otolaryngol 1985;111:34-38)

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