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February 1985

Cisplatin Potentiation of Radiotherapy: Long-term Follow-up

Author Affiliations

From the Department of Otolaryngology and Maxillofacial Surgery (Drs Leipzig, Wetmore, Suen, and Snyderman), and the Department of Radiology (Dr Putzeys), Division of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock.

Arch Otolaryngol. 1985;111(2):114-118. doi:10.1001/archotol.1985.00800040078011

• Thirty-three patients with inoperable squamous cell carcinoma of the head and neck were treated with cisplatin, 15 mg/sq m, administered synchronously with high-dose radiation therapy. Twenty-nine patients (88%) responded to the regimen; of these, 20 had complete regression of all disease. Eight of the 20 had a relapse in less than one year of their treatment. Among those patients who did not have a relapse, the follow-up period was short. It is concluded that a clinical regression response is more likely with this treatment regimen than with radiation therapy alone, and that that response may be a better palliation. Further study of this combination of treatment modalities is warranted.

(Arch Otolaryngol 1985;111:114-118)