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February 1986

Cefazolin vs Moxalactam?A Double-blind Randomized Trial of Cephalosporins in Head and Neck Surgery

Author Affiliations

From the Department of Otolaryngology, Eye and Ear Hospital, University of Pittsburgh School of Medicine.

Arch Otolaryngol Head Neck Surg. 1986;112(2):151-153. doi:10.1001/archotol.1986.03780020031008

• Cefazolin and moxalactam were compared in a prospective randomized double-blind trial of 118 patients undergoing oncologic head and neck surgery. Both antibiotics were given 2 g every four hours for four doses. Five infections were encountered in the cefazolin group (8.5%) and two infections in the moxalactam group (3.4%); this difference was not statistically significant. This assessment does not indicate, however, that the two regimens are equally efficacious.

(Arch Otolaryngol Head Neck Surg 1986;112:151-153)