• We evaluated postoperative complications in a randomized series of patients with head and neck cancer who received preoperative chemotherapy. Forty-two patients with advanced squamous carcinoma of the head and neck were randomized to receive either high-dose metho-trexate with leucovorin calcium rescue (23 patients) or no chemotherapy (19 patients) prior to definitive conventional treatment. The two groups of patients were balanced by sex, disease site, stage, histologic grade, and prior therapy. Sixteen of the 23 patients receiving preoperative chemotherapy had postoperative complications, whereas only eight of 19 patients not receiving chemotherapy had postoperative complications. Surgical complications included wound infections, orocutaneous fistulas, and flap necrosis.
(Arch Otolaryngol Head Neck Surg 1986;112:437-439)
Corey JP, Caldarelli DD, Hutchinson JC, et al. Surgical Complications in Patients With Head and Neck Cancer Receiving Chemotherapy. Arch Otolaryngol Head Neck Surg. 1986;112(4):437–439. doi:10.1001/archotol.1986.03780040077016
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