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May 1986

Oncocytic and Oncocytoid Carcinoid Tumors (Well-Differentiated Neuroendocrine Carcinomas) of the Larynx

Author Affiliations

From the Department of Otorhinolaryngology (Drs Stanley and DeSanto) and Section of Surgical Pathology (Dr Weiland), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Otolaryngol Head Neck Surg. 1986;112(5):529-535. doi:10.1001/archotol.1986.03780050053009

• Carcinoid tumors of the larynx are exceedingly rare neoplasms. With the inclusion of the five neoplasms we report herein, the total number reported in the English-language literature is 16. These five neoplasms all showed light microscopic features of oncocytic (or oncocytoid) cells. Ultrastructurally, all lesions contained dense-core granules of the neurosecretory type. One case further met the ultrastructural criteria for true oncocytoma (that is, an oncocytic carcinoid). The lesion did not metastasize, and the patient was successfully treated surgically. In the other four cases, the lesions were considered to be oncocytoid carcinoids, since they failed to meet the ultrastructural requirements of a true oncocytoma. Each of these four lesions metastasized, although one patient did have a long, indolent course.

(Arch Otolaryngol Head Neck Surg 1986;112:529-535)