[Skip to Navigation]
[Skip to Navigation Landing]
August 1986

Prognostic Significance of Thyroid Gland Involvement in Laryngeal Carcinoma

Author Affiliations

From the Departments of Otolaryngology (Drs Gilbert, van Nostrand, and Bryce) and Pathology (Dr van Nostrand), University of Toronto; the Royal Hospital, Wolverhampton, England (Dr Cullen); and the Department of Radiation Oncology, Princess Margaret Hospital, Toronto (Dr Harwood).

Arch Otolaryngol Head Neck Surg. 1986;112(8):856-859. doi:10.1001/archotol.1986.03780080056012

• We reviewed 173 laryngeal specimens that included thyroid tissue received from patients undergoing laryngectomy between 1966 and 1980 for evidence of thyroid gland invasion. Twenty-three (14%) of the larynges demonstrated thyroid involvement. In 15 specimens, involvement of the thyroid gland was by direct extension, and in eight the thyroid was involved metastatically. The survival in this group of patients was poor, with 18 patients dying of their disease within three years. Subglottic extension of 10 mm or greater was noted in 21 of 23 patients, and local recurrence was noted in 15 of 18 patients dying of their disease. The importance of removing one or both lobes of the thyroid gland in advanced laryngeal cancer is restated, and a surgically aggressive approach to the paratracheal nodes is recommended in patients with extensive subglottic involvement.

(Arch Otolaryngol Head Neck Surg 1986;112:856-859)