• Antibodies to intermediate filaments and to desmoplakin were used to investigate the histogenetic origin of the olfactory neuroepithelium. Intermediate-filaments are tissue-specific molecular cytoskeletal markers; desmoplakin is the major desmosomal protein. The olfactory epithelia of eight human fetuses, aged 7 to 10 weeks (fertilization age) were immunofluorescently labeled with antibodies to the five classes of intermediate-filament proteins and to desmoplakin. Positive immunoreactivity to keratin and to desmoplakin was observed; both results indicate the epithelial nature of this tissue. The absence of neurofilaments and glialfibrillary acidic protein in the tissue containing sensory neurons and gliallike supporting cells is a unique feature, and may be related to the fact that olfactory neuroepithelium, like other epithelia, undergoes continuous turnover.
(Arch Otolaryngol Head Neck Surg 1987;113:155-159)
Ophir D. Intermediate Filament Expression in Human Fetal Olfactory Epithelium. Arch Otolaryngol Head Neck Surg. 1987;113(2):155–159. doi:10.1001/archotol.1987.01860020047010
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