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February 1987

Cold Air–Induced Rhinorrhea and High-Dose Ipratropium

Author Affiliations

From the Otopathological Laboratory, Department of Otorhinolaryngology, Rigshospitalet, Copenhagen.

Arch Otolaryngol Head Neck Surg. 1987;113(2):160-162. doi:10.1001/archotol.1987.01860020052011

• A high dose of the cholinoceptor antagonist ipratropium bromide, in the form of a nasal spray, was tested on cold air– and hot soup–induced rhinorrhea in order to determine to what extent these types of rhinorrhea are reflex-mediated hypersecretions from nasal glands. Fourteen normal volunteers were examined in a placebo-controlled study. A single dose of ipratropium bromide (400 μg) caused a 73% reduction of cold air–induced rhinorrhea and a 66% reduction of hot soup– induced rhinorrhea. It is concluded that a major part of the nasal discharge induced by these stimuli is reflex-mediated, and consequently may be treated by a cholinoceptor antagonist, such as ipratropium.

(Arch Otolaryngol Head Neck Surg 1987;113:160-162)

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