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April 1987

Sinonasal Undifferentiated Carcinoma

Author Affiliations

Galveston, Tex

Arch Otolaryngol Head Neck Surg. 1987;113(4):355. doi:10.1001/archotol.1987.01860040015001

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Paul A. Levine, MD, and collaborators at the University of Virginia, Charlottesville, recently reported 11 cases of undifferentiated carcinoma of the nose and sinuses whose features were pathologically and clinically distinct from those of other malignancies at these sites. Their report, presented at the Southern Section Meeting of the Triological Society in Santa Fe, NM, emphasized the aggressive nature of this neoplasm, which they called sinonasal undifferentiated carcinoma. Six of the patients had orbital involvement, and seven had anterior cranial fossa involvement. Most patients' tumors were unresectable (seven of 11), and the patients received chemotherapy and radiotherapy. Eight (73% ) of 11 patients died with disease, and, of the three still living, only one is free of disease. The authors stated that presenting symptoms are not unlike those of other tumors that arise in these sites, and the differential diagnosis should include esthesioneuroblastoma, melanoma, rhabdomyosarcoma, neuroendocrine carcinoma, and lymphoepithelioma. Special histologic

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