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April 1987

Cochlear Ototoxicity of Neomycin and Polymyxin B Following Middle Ear Application in the Chinchilla and Baboon

Author Affiliations

Chapel Hill, NC

Arch Otolaryngol Head Neck Surg. 1987;113(4):355. doi:10.1001/archotol.1987.01860040015002

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In an effort to compare the ototoxicity of polymyxin B sulfate and neomycin sulfate topically applied to the middle ear of two species of animals, W. L. Meyerhoff, MD, and C. G. Wright, MD, of the University of Texas, Dallas, studied the cochleae of chinchillas and baboons after the topical application of a commercially available preparation (Cortisporin). Ten chinchilla temporal bones were studied after a middle ear instillation of 0.5 mL of neomycin sulfate solution, and another group of ten specimens were evaluated after the application of the same volume of polymyxin B sulfate solution. The animals were killed two days to four weeks after the administration of the drugs. There were marked degenerative changes in the basilar membrane and stria vascularis in animals exposed to polymyxin B, but very little in animals exposed to neomycin. When neomycin-induced ototoxicity was encountered, it was confined only to the most basilar turn

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