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Article
April 1987

Electrical Stimulation of the Guinea Pig Cochlea

Arch Otolaryngol Head Neck Surg. 1987;113(4):357. doi:10.1001/archotol.1987.01860040017005

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Abstract

In this straightforward study, Mark J. Maslan, MD, and Josef Miller, PhD, of the University of Michigan, Ann Arbor, examined the morphological and functional effects of electrical stimulation on the cochlea. One arm of the study included implantation of the electrode into the scala tympani through the round window. In the other arm of the study, the electrode was placed in the round-window niche. Auditory brain-stem responses were obtained before and after each of four three-hour stimulation sessions. Six weeks after the implants were placed, the animals were killed and the cochleae were examined for potential damage. The threshold required to elicit damage when intracochlear electrodes were used was less than half that required to cause the same response with extracochlear electrodes. Auditory brain-stem response alterations could not predictably be related to the degree and site of cochlear histopathologic damage.

The results of Maslan and Miller's study demonstrate that stimulation

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