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April 1987

Treatment of Scleroma With Ceforanide

Author Affiliations

From the Eisenhower Medical Center, Rancho Mirage, Calif.

Arch Otolaryngol Head Neck Surg. 1987;113(4):374-376. doi:10.1001/archotol.1987.01860040036012

• Three patients with rhinoscleroma who presented with nasal and pharyngeal symptoms are described. Treatment with ceforanide, a new second-generation cephalosporin with high intrinsic activity against Klebsiella, and possessing a long half-life, was used as outpatient treatment. A total of 120 g of ceforanide was administered over a period of two months. All three patients showed signs of clinical improvement, but only two of three became bacteriologically sterile at the end of two months; one patient relapsed bacteriologically but not clinically, once the drug was discontinued. Second- and third-generation cephalosporins appear to have excellent activity against the causative pathogens of rhinoscleroma. Because of the impracticality of administering these agents parenterally over prolonged periods of time, there is a need for the development of an oral cephalosporin with similar intrinsic activity and β-lactamase stability. Perhaps the novel β-lactam antibiotics such as the penems and monobactams, some of which can be administered orally, will answer that need.

(Arch Otolaryngol Head Neck Surg 1987;113:374-376)

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