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August 1987

In Situ Hybridization of Papillomavirus DNA in Head and Neck Squamous Cell Carcinomas

Author Affiliations

From the Department of Anatomic Pathology, Division of Pathology (Drs Dekmezian and Batsakis), and the Department of Head and Neck Surgery, Division of Surgery (Dr Goepfert), The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston.

Arch Otolaryngol Head Neck Surg. 1987;113(8):819-821. doi:10.1001/archotol.1987.01860080025008

• Cytospin preparations of fine-needle aspirates obtained from five squamous cell carcinomas of the head and neck (four metastatic in lymph nodes and one primary) were tested for human papillomavirus (HPV) genotypes 6, 11, 16, and 18 by in situ hybridization using biotinylated DNA probes. All five carcinomas showed hybridization with HPV-11, four strongly reactive, and one also weakly hybridized with HPV-16. Genotypes 6 and 18 showed no evidence of hybridization.

(Arch Otolaryngol Head Neck Surg 1987;113:819-821)

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