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September 1987

Effects of Pentoxifylline on Experimental Skin Flap Survival

Author Affiliations

From the Department of Otolaryngology, Oregon Health Sciences University, Portland.

Arch Otolaryngol Head Neck Surg. 1987;113(9):950-952. doi:10.1001/archotol.1987.01860090048017

• We studied the effects of pentoxifylline on experimental skin flap survival in the domestic pig. Random skin flaps were designed using a length-width ratio of 5:1. The pigs were then given pentoxifylline (25 mg/kg/d) or placebo for seven days. Fluorescein sodium was used to help determine surviving skin flap length seven days postoperatively. Results showed no significant difference in mean surviving skin flap length between the study and control groups. We question the value of pentoxifylline in increasing skin flap survival.

(Arch Otolaryngol Head Neck Surg 1987;113:950-952)

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