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October 1987

Chemotherapy of Bilateral Acoustic Neuromas

Arch Otolaryngol Head Neck Surg. 1987;113(10):1042. doi:10.1001/archotol.1987.01860100020002

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A novel approach for the management of bilateral acoustic neuromas in patients with Recklinghausen's disease was reported by Drs Robert Jahrsdoerfer and Robert Benjamin from the Department of Otolaryngology–Head and Neck Surgery, University of Texas Medical School, Houston, and the Department of Medical Oncology, M. D. Anderson Hospital and Tumor Institute, Houston, at the Denver meeting of the American Neurotological Society. Previous attempts at preserving hearing in this patient population have been uniformly poor. The reasons for this have been attributed to the aggressive nature of the tumors to invade the cochlear nerve and otic capsule.

Two adults with bilateral acoustic neuromas caused by Recklinghausen's disease were treated with a combination chemotherapy regimen consisting of doxorubicin hydrochloride, cyclophosphamide, and dacarbazine. One patient received one treatment per month for six months while the other patient received five treatments over five months. Posttreatment imaging studies indicate no increase in tumor size at

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