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October 1987

Effect of Ligating Peripheral Branches on Facial Nerve Regeneration

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Arch Otolaryngol Head Neck Surg. 1987;113(10):1046-1047. doi:10.1001/archotol.1987.01860100024012

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Douglas Mattox, MD, of the Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, presented the results of his investigation into the effect of selectively ligating peripheral branches of the facial nerve in promoting regeneration of more important branches of the nerve at the American Neurotology Society Meeting, Denver, April 24 to 25, 1987.

Based on clinical observations made by his coauthor, Dr Ugo Fisch, Zurich, that ligation of the central branches of the facial nerve after grafting or primary anastomosis will promote regeneration at the mouth and eye, Drs Mattox, Fisch, and Jacob Felix, Baltimore, designed an animal (rat) model for the study of this phenomenon.

Bilateral common trunk facial nerve transections were performed. Following reanastomosis, all peripheral branches except the mandibular branch were ligated on one side. The contralateral side served as a nonligated control. Over a six-month period, selective electrophysiologic studies (compound action potential latencies) and

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