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November 1987

Astemizole for Treatment of Chronic Vertigo-Reply

Arch Otolaryngol Head Neck Surg. 1987;113(11):1239-1240. doi:10.1001/archotol.1987.01860110105024

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In Reply.—We appreciate Dr Wexler's careful reading of our article, and we share his mistrust of data purporting to show a beneficial effect of a drug on chronic dizziness.

Can we attribute our results to a drug effect? There did not seem to be a best way to present the data from a relatively small pool of patients that had been treated with three doses of drug in three different sequences. We carefully chose our illustrations so as to best demonstrate the many facets of the responses. Figure 5 showed a typical variation in nystagmic beats over the course of the study in a nonresponder. In our discussion, we stated that the average nystagmus after one week of placebo was 135% of the control value. It never dropped lower than 86.9% of the control value. Also, we stated that 26 of the 28 responders evidenced a return of nystagmus

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