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January 1988

Persistence and Expression of Human Papillomavirus During Interferon Therapy

Author Affiliations

From the Department of Otolaryngology, Long Island Jewish Medical Center, New Hyde Park (Drs Steinberg and Abramson and Mr Gallagher), and the Department of Pathology, University of Rochester Medical Center (Dr Stoler), NY.

Arch Otolaryngol Head Neck Surg. 1988;114(1):27-32. doi:10.1001/archotol.1988.01860130031010

• Alpha interferon did not prevent the persistence or expression of human papillomavirus (HPV) types 6 or 11 in respiratory tract papillomas. Seventeen patients receiving interferon therapy for a minimum of six months and a maximum of 39 months still had one to ten copies per cell genome of HPV DNA in their laryngeal tissues, seen by Southern blot hybridization. In papillomas that recurred during treatment, HPV RNA could be detected by in situ hybridization, and capsid protein could be detected by immunoperoxidase staining. Persistence of the HPV DNA, and recurrences that occurred during therapy, are attributed to the failure of interferon therapy to eliminate latent virus.

(Arch Otolaryngol Head Neck Surg 1988;114:27-32)

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