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January 1988

Nasal Pharmacodynamics of Brompheniramine in Perennial Rhinitis

Author Affiliations

From the Section of Allergy and Clinical Immunology, Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC (Dr Georgitis), and the Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle (Dr Shen).

Arch Otolaryngol Head Neck Surg. 1988;114(1):63-67. doi:10.1001/archotol.1988.01860130067017

• This study evaluated the relationship between brompheniramine maleate and changes in nasal reactivity. Ten subjects with moderate-to-severe perennial rhinitis took brompheniramine for seven days using either a standard formulation or sustained-release preparation. Nasal aerodynamics and response to histamine were assessed at the end of the week. Despite varying doses of brompheniramine maleate (12 to 32 mg/d), there was no significant difference in nasal reactivity to histamine or in changes of nasal airflow, indicating that low doses of brompheniramine are highly effective in blocking histamine1 receptors in the nasal mucosa.

(Arch Otolaryngol Head Neck Surg 1988;114:63-67)