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February 1988

Compatibility of Autologous Fibrin Adhesive With Implant Materials

Author Affiliations

From the Departments of Otolaryngology (Drs Feldman and Sataloff), Pathology (Dr Choi), and Medicine (Dr Ballas), Cardeza Foundation, Jefferson Medical College of Thomas Jefferson University, Philadelphia.

Arch Otolaryngol Head Neck Surg. 1988;114(2):182-185. doi:10.1001/archotol.1988.01860140080026

• A safe, effective method for securing autologous and alloplastic implants would benefit modern surgery substantially. We studied the effects of a new autologous fibrin tissue adhesive with various alloplastic implants and ear cartilage. Twelve rabbits had Proplast (a woven combination of Teflon and organic fibers), Silastic, Supramid polyfilament surgical sheeting, and ear cartilage implanted. One side of each animal had implants secured with tissue adhesive. The other, control side had identical implants placed in "subcutaneous tunnels." The tissue adhesive was biodegradable and produced no apparent toxic reaction, infection, or foreign-body reaction. It did not adhere to Silastic, but bound to the other implants. Glued implants had no more clinical or histologic evidence of inflammation than controls. Autologous fibrin tissue adhesive seems to be promising as a safe, biologic bonding material for securing certain alloplastic and autologous implants.

(Arch Otolaryngol Head Neck Surg 1988;114:182-185)

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