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March 1988

Small-Cell Carcinoma of the Parotid Gland With Neuroendocrine Features

Author Affiliations

From the Departments of Otolaryngology—Head and Neck Surgery (Drs Scher and Levine) and Pathology (Dr Feldman), University of Virginia Medical Center, Charlottesville.

Arch Otolaryngol Head Neck Surg. 1988;114(3):319-321. doi:10.1001/archotol.1988.01860150101023

• An 82-year-old woman had a small-cell carcinoma of the parotid gland with cells containing neuroendocrine secretory granules. To our knowledge, these dense-core granules have been identified in only three other major salivary gland small-cell carcinomas. The findings of histologic and ultrastructural evaluations of this neoplasm suggested a salivary duct cell origin. The tumor appears to arise from cells of the salivary duct system that differentiate into cells with either neuroendocrine or epithelial features. Electron microscopy to determine the type of small-cell carcinoma should be performed, as this may have prognostic significance. Aggressive therapy should be undertaken, since small-cell carcinomas of the major salivary glands appear to have a better prognosis than bronchogenic or laryngeal small-cell carcinomas have.

(Arch Otolaryngol Head Neck Surg 1988;114:319-321)