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April 1988

Phototherapy With the Argon Laser on Human Melanoma Cells 'Sensitized' With Rhodamine 123: A New Method for Tumor Growth Inhibition

Author Affiliations

Los Angeles

Arch Otolaryngol Head Neck Surg. 1988;114(4):373. doi:10.1001/archotol.1988.01860160015005

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Dan J. Castro, MD, and coworkers at UCLA presented their data using rhodamine 123 as a photosensitizing agent for argon laser. This report was given at the Western Section meeting of the Triological Society in San Diego. They found complete inhibition of in vivo tumor development by human M24 melanoma cells transplanted subcutaneously into mice after exposure to low-dose rhodamine 123 and treatment with an argon laser at nonthermal temperatures of 36°C to 40°C. This study shows remarkable tumoricidal effects of nonthermal argon when the mitochondrial dye, rhodamine 123, has been employed prior to laser therapy.—

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