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May 1988

Morphologic and Physiologic Changes in the Inner Ear After Viral Infection of the Endolymphatic Sac

Author Affiliations

Nashville, Tenn

Arch Otolaryngol Head Neck Surg. 1988;114(5):489. doi:10.1001/archotol.1988.01860170015008

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At the annual meeting of the American Academy of Otolaryngology-Head Neck Surgery in Chicago, Drs Fukuda, Keithley, and Harris, San Diego and La Jolla (Calif), reported that the etiology of endolymphatic hydrops remains unproven. One proposed mechanism is that hydrops occurs following a viral infection of the endolymphatic sac. The authors presented a model to study viral infection of the endolymphatic sac. The model used guinea pigs and a strain of guinea pig–specific cytomegalovirus (CMV). Cytomegalovirus was injected into the endolymphatic sac through a posterior fossa approach. In cases where a live virus was injected into the endolymphatic sac, significant endolymphatic hydrops was found on histologic section. In cases where inactivated CMV was injected into the endolymphatic sac, no hydrops was found. In animals that had been previously sensitized to CMV and had developed antibodies, injection of the live virus resulted in no formation of hydrops. Previous immunization apparently provided

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