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Clinicians continue to look for methods of treating advanced head and neck cancer through the use of drugs and/or irradiation that will give comparable or better results than those obtained with surgery. Kadish et al reported on the efforts of St Vincent's Hospital in Worcester, Mass, to achieve this goal.
A series of 52 previously untreated patients with advanced head and neck cancer (stages III and IV) seen between 1978 and 1985 and treated with induction (neoadjuvant) chemotherapy followed by radiation therapy as definitive treatment was retrospectively reviewed and reported at the Second International Head and Neck Oncology Research Conference.
The study group included 38 males and 14 females with a median age of 62 years. Anatomic sites included oral cavity (14), oropharynx (18), hypopharynx (8), larynx (9), and unknown primary (3). All patients had squamous cell carcinoma. Seventy-three percent of the group had stage IV cancer. Patients were either
BAKER SR. Methods of Treating Advanced Head and Neck Cancer. Arch Otolaryngol Head Neck Surg. 1988;114(6):620–621. doi:10.1001/archotol.1988.01860180034023
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