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June 1988

Preservation of Laryngeal Function in Patients With Carcinoma of the Larynx

Author Affiliations

Ann Arbor, Mich.

Arch Otolaryngol Head Neck Surg. 1988;114(6):621. doi:10.1001/archotol.1988.01860180035025

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In an effort to preserve laryngeal function in patients with carcinoma of the larynx, Wolf et al reported on a new strategy in treatment at the recent Second International Head and Neck Oncology Research Conference held in Arlington, Va.

In 1985, the Veterans Administration cooperative study program initiated a prospective, randomized multi-institutional study of the effectiveness of induction chemotherapy (CT) and radiation therapy (RT) compared with surgery and postoperative RT in patients with stage III/IV laryngeal squamous carcinoma. Induction CT (cisplatin, 100 mg/m2 administered intravenously on day 1, and fluorouracil, 1000 mg/m2 in a 24-hour infusion on days 1 through 5) was repeated on days 1, 22, and 43. Tumor response was assessed after two cycles; responders received a third cycle followed by tumor biopsy and RT (66 to 76 Gy [6600 to 7600 rad]). Patients having less than a partial response (PR) had salvage laryngectomy and RT.

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