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July 1988

The Effect of Hyperbaric Oxygen Therapy on Oral Cavity Carcinoma

Author Affiliations

Durham, NC

Arch Otolaryngol Head Neck Surg. 1988;114(7):711. doi:10.1001/archotol.1988.01860190015003

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At the Southern Section meeting of the Triological Society in Birmingham, Ala, Terry McMillan and coworkers from the University of Texas at Galveston presented a well-controlled study of chemically induced squamous cell carcinoma in hamsters to determine the effects of hyperbaric oxygen on tumor growth, differentiation, depth of invasion, and number of developing tumors. Their study demonstrated no effect of hyperbaric oxygen on the microscopic analysis of the tumor, but an increase in the cross-sectional area of tumor in animals receiving the carcinogen with hyperbaric oxygen. These animals had fewer tumors develop but those that did develop had larger lesions than the animals receiving the carcinogen without hyperbaric oxygen. Possible mechanisms causing these changes were discussed briefly.

Comment.—Whereas this paper provided useful basic science data on the effects of standard hyperbaric oxygen on chemically induced squamous cell carcinoma using an animal model, extrapolation and clinical application of their conclusions

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