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Article
July 1988

Role of Chemotherapy in Management of Patients With Cancer of the Paranasal Sinuses

Author Affiliations

Ann Arbor, Mich

Arch Otolaryngol Head Neck Surg. 1988;114(7):721. doi:10.1001/archotol.1988.01860190025013

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Abstract

The role of chemotherapy in the management of patients with cancer of the paranasal sinuses is not presently defined. An analysis of 21 patients treated with chemotherapy as part of their overall therapy was reported by Tapazoglou and colleagues from Wayne State University and Harper Grace Hospitals, Detroit. They reported on 14 males and seven females at the Second International Head and Neck Oncology Research Conference. Thirteen patients previously untreated made up group A and eight patients who had presented with recurrent disease after surgery and/or radiotherapy made up group B. Six of the patients in group A had distant metastatic disease on presentation (four, central nervous system [CNS]; two, lung) and four patients in group B had CNS involvement. The majority of the patients (81%) had squamous cell carcinoma. The chemotherapy regimen included cisplatin, oncovin, and bleomycin (COB), or fluorouracil infusion and cisplatin combinations. Computed tomographic scans were used

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