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July 1988

Rhinocerebral Mucormycosis With Cerebral Extension Successfully Treated With Adjunctive Hyperbaric Oxygen Therapy

Author Affiliations

From the Department of Internal Medicine, Division of Infectious Diseases (Drs Couch and Mader), the Department of Otolaryngology (Dr Theilen), and the Marine Biomedical Institute (Dr Mader), The University of Texas Medical Branch, Galveston.

Arch Otolaryngol Head Neck Surg. 1988;114(7):791-794. doi:10.1001/archotol.1988.01860190095032

• Rhinocerebral mucormycosis is a devastating fungal disease with a high mortality rate. Extensive surgical débridement and amphotericin B are currently the mainstays of therapy. When cerebral extension of the fungus occurs, the disease is almost invariably fatal. Two patients with rhinocerebral mucormycosis had progression of their infection to brain abscesses despite aggressive débridement surgery and amphotericin B therapy. Both patients showed marked clinical improvement with the addition of adjunctive hyperbaric oxygen therapy. Both patients remained free of their disease 21 months after hospital discharge.

(Arch Otolaryngol Head Neck Surg 1988;114:791-794)