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August 1988

Growth Factors and Wound Repair

Arch Otolaryngol Head Neck Surg. 1988;114(8):848-849. doi:10.1001/archotol.1988.01860200032009

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Growth factors are a recently discovered group of polypeptides that play an important role in wound healing, cell regulation and proliferation, and oncogenesis. With the recognition of these substances, there has been a revised look at the sequence of wound healing.

The traditional understanding of wound healing involves three phases: inflammation, collagen deposition, and maturation. Newer approaches have refined the inflammatory phases into an early migration of cells into the wound, which is influenced by chemoattractants. This preliminary pathophysiologic event is followed by growth factor-influenced proliferation of these inflammatory cells.

Polypeptide growth factors exert their action on specific complexes external to the target cell, and cause a characteristic and/or hyperplastic target cell response. Growth factors differ from hormones by their mode of action. Their effect can be local, either on cells adjoining the producer cell (paracrine action) or on the secreting cell itself (autocrine action). The normal cell, therefore, requires

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