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August 1988

Suppression of Immune-Mediated Otitis Media by T-Suppressor Cells

Author Affiliations

From the Department of Otolaryngology, Medical College of Oita (Japan).

Arch Otolaryngol Head Neck Surg. 1988;114(8):878-882. doi:10.1001/archotol.1988.01860200062019

• Effects of mucosa-derived T-suppressor cells on induction of IgG-mediated otitis media with effusion (OME) were investigated in mice, since antigenantibody reactions in the tympanic cavity are pathogenic mechanisms of OME. Splenic T-suppressor cells from strain C3H/HeN female mice, to which ovalbumin (OVA) had been orally administered, were transferred intravenously to syngeneic mice. The mice receiving the T-suppressor cells were immunized with OVA intraperitoneally and then injected with OVA into the tympanic cavity. Nine of ten control mice, to which splenic T cells from saline-fed mice were administered, developed OME, while OME was seen in only one of ten mice receiving splenic T cells from OVA-fed mice. The results show that IgG-mediated OME can be suppressed to a certain extent by the induction of antigen-specific, mucosa-derived, T-suppressor cells.

(Arch Otolaryngol Head Neck Surg 1988;114:878-882)