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Michael S. Benninger, MD, and collaborators at the Cleveland Clinic Foundation recently reported 41 cases of squamous cell carcinoma of the head and neck in patients 40 years of age and younger. In this retrospective review of cases observed between 1977 and 1985, which was presented at the Middle Section meeting of the Triological Society, Ann Arbor, Mich, the majority of patients were white males with a history of heavy smoking and alcohol abuse. The larynx, oral cavity, and nasopharynx were the most frequent tumor sites in this patient group. There was a fairly equal distribution of patients among the four stages of disease. The majority of patients (28 of 41) were treated with a combination of radiation therapy and surgery. Twenty-one (51%) of 41 patients died of their disease; 61% of these 21 died of distant disease, despite aggressive local and regional management. The authors concluded that younger patients
SULLIVAN MJ. Squamous Cell Carcinoma of the Head and Neck in Patients 40 Years of Age and Younger. Arch Otolaryngol Head Neck Surg. 1988;114(9):949. doi:10.1001/archotol.1988.01860210015001
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