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Article
September 1988

Histopathologic and Virologic Study in Squamous Carcinoma Arising From Established Benign Papillomata

Arch Otolaryngol Head Neck Surg. 1988;114(9):949. doi:10.1001/archotol.1988.01860210015003

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Abstract

Haskins Kashima and coworkers at Johns Hopkins University School of Medicine, Baltimore, recently reported a case of squamous cell carcinoma arising in a laryngeal papilloma in an adult who had had irradiation 14 years previously. Further investigation of this case, presented at the Southern Section of the Triological Society in Birmingham, Ala, disclosed widespread distribution of human papillomavirus in the laryngectomy specimen. Of the 17 previously reported cases of carcinoma in laryngeal papilloma, ten cases had had radiation therapy for treatment of the papillomas. The latency between the diagnosis of papilloma and the development of carcinoma was approximately 30 years in the nonirradiated cases, but it was only ten years in the irradiated cases. Careful histologic examination of the specimen was urged after any papilloma removal for early detection of carcinoma.

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