This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
At the January 1988 meeting of the Western Section of the Triological Society, Robbins and collaborators from the University of Texas–M. D. Anderson Hospital, Houston, reported their results of a prospective randomized study of patients undergoing head and neck oncologic surgical procedures. The patients were divided in two groups: group A received cefazolin, 1000 mg intravenously (IV) one hour preoperatively and 500 mg every eight hours for a total of six doses, and metronidazole (Flagyl), 500 mg IV one hour preoperatively and 250 mg IV every eight hours postoperatively for six doses. Group B received cefazolin alone in the same dosage and regimen.
The rate of wound infection in group A (158 patients) was 9.5% compared with 18.6% in group B (172 patients) (P =.03). Patients undergoing clean procedures had a 4.9% infection rate compared with clean-contaminated and contaminated procedures, which had a higher infection rate of 3.5-fold and 6.5-fold,
MANIGLIA AJ. Wound Prophylaxis With Metronidazole in Head and Neck Surgical Oncology. Arch Otolaryngol Head Neck Surg. 1988;114(10):1083. doi:10.1001/archotol.1988.01860220017001
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: