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October 1988

Pharmacologic Enhancement of Flap Survival

Arch Otolaryngol Head Neck Surg. 1988;114(10):1102. doi:10.1001/archotol.1988.01860220036018

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A series of papers presented at the 1988 spring meeting of the American Academy of Facial Plastic and Reconstructive Surgery in Palm Beach, Fla, addressed the problem of pharmacologic enhancement of skin flap survival in some interesting and innovative ways.

David B. Hom, MD, Shan R. Baker, MD, and Ken D. McClatchey, MD, Ann Arbor, Mich, treated island skin flaps in rabbits with angiogenic agents. There were 84 island skin flaps created on the auricles of New Zealand white rabbits. On day 3 postoperatively, the vascular pedicles were ligated to create partial flap necrosis. Thirty-six flaps were treated with endothelial growth supplement and endothelial cell–growth factor; the remainder were used as controls. The angiogenic agents were applied either topically or impregnated in Gelfoam placed under the flaps. In addition to a standard measurement of flap viability, the peripheral neovascularization was documented by angiograms and magnified with mammography techniques. The endothelial

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