This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
A series of papers presented at the 1988 spring meeting of the American Academy of Facial Plastic and Reconstructive Surgery in Palm Beach, Fla, addressed the problem of pharmacologic enhancement of skin flap survival in some interesting and innovative ways.
David B. Hom, MD, Shan R. Baker, MD, and Ken D. McClatchey, MD, Ann Arbor, Mich, treated island skin flaps in rabbits with angiogenic agents. There were 84 island skin flaps created on the auricles of New Zealand white rabbits. On day 3 postoperatively, the vascular pedicles were ligated to create partial flap necrosis. Thirty-six flaps were treated with endothelial growth supplement and endothelial cell–growth factor; the remainder were used as controls. The angiogenic agents were applied either topically or impregnated in Gelfoam placed under the flaps. In addition to a standard measurement of flap viability, the peripheral neovascularization was documented by angiograms and magnified with mammography techniques. The endothelial
LARRABEE WF. Pharmacologic Enhancement of Flap Survival. Arch Otolaryngol Head Neck Surg. 1988;114(10):1102. doi:10.1001/archotol.1988.01860220036018
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: