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November 1988

The Use of Injectable Human Fibroblasts

Author Affiliations

Durham, NC

Arch Otolaryngol Head Neck Surg. 1988;114(11):1228. doi:10.1001/archotol.1988.01860230022007

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At the recent spring meeting of the American Academy of Facial Plastic and Reconstructive Surgery in Palm Beach, Fla, Dr Dan Remmler, Scottsdale, Ariz, and coworkers presented data on the experimental use of cultured human fibroblasts and/or Zyderm collagen (injectable bovine collagen, Collagen Corp, Palo Alto, Calif) for soft-tissue augmentation.

Cultured human fibroblasts (HFb), Zyderm II injectable bovine collagen (Zyd), HFb and Zyd, and Zyplast-injectable, glutaraldehyde-treated, bovine collagen (Zyp) were injected into 17 athymic nude mice. Balanced salt solution was used as a control. Each mouse received 0.5 mL of each substance by subcutaneous injection; HFb, HFb and Zyd, Zyd, and balanced salt solution were injected into the dorsum, and Zyp was injected into the ventral surface. Nodular swellings resulting from the subcutaneous injections were measured immediately following injection. At ten days and nine weeks, the volume was again measured, and the implants were examined histologically.

At nine weeks, HFb

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