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November 1988

β2-Microglobulin in Otitis Media With Effusion

Author Affiliations

From the Otological Research Laboratories, Department of Otolaryngology, Ohio State University College of Medicine, Columbus.

Arch Otolaryngol Head Neck Surg. 1988;114(11):1259-1261. doi:10.1001/archotol.1988.01860230053022

• β2-Microgobulin (β2M) is a low-molecular-weight protein present in serum and other fluids during various autoimmune or chronic inflammatory diseases. β2-Microglobulin was measured in middle ear effusion (MEE) and serum samples obtained from 36 patients with chronic otitis media with effusion. Using a quantitative competitive enzyme immunoassay, we were able to demonstrate β2M in 98% of the MEE samples. The mean concentration of β2M was higher in the MEE samples than in the serum samples. There was considerable variability between ears in those patients with bilateral MEE. There was no correlation between β2M concentration and the patients' age, sex, MEE type, and culture results, or cytologic profiles of the MEEs. This increased β2M may reflect earlier lymphocyte activity during the inflammatory process.

(Arch Otolaryngol Head Neck Surg 1988;114:1259-1261)