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January 1989

Long-term Follow-up of Chemotherapy in Advanced Head and Neck Cancer

Author Affiliations

From the Oncology Section, Veterans Administration Medical Center, Buffalo (Dr Spaulding), and the Department of Otolaryngology, State University of New York at Buffalo School of Medicine (Drs Spaulding and Lore and Ms Sundquist).

Arch Otolaryngol Head Neck Surg. 1989;115(1):68-73. doi:10.1001/archotol.1989.01860250070030

• We treated 94 patients with advanced head and neck cancer with a combined-modality protocol that included induction chemotherapy followed by surgery with and without radiotherapy. With a minimum follow-up of 3½ years, 33 (35%) of the patients were alive and disease free. Thirty (32%) of the patients died of recurrent head and neck cancer. Complete response to chemotherapy and initial tumor bulk correlated with prolonged disease-free survival. Site of disease had no effect. There appeared to be no advantage to the use of routine post-operative radiotherapy in these advanced tumors.

(Arch Otolaryngol Head Neck Surg 1989;115:68-73)

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