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February 1989

Mandibular Osteoradionecrosis

Author Affiliations

Durham, NC

Arch Otolaryngol Head Neck Surg. 1989;115(2):141. doi:10.1001/archotol.1989.01860260015007

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On Sept 27, 1988, during the annual meeting of the American Academy of Otolaryngology–Head and Neck Surgery in Washington, DC, Robert P. Johnson, MSD, DDS, University of Texas Dental and Medical Schools, San Antonio, presented an invited review on mandibular osteoradionecrosis and the role of hyperbaric oxygen treatments at the scientific sessions of the Head and Neck Surgery Oncology Committee. The author's abstract, which follows, is a good review of this informative presentation.

Osteoradionecrosis (ORN) of the jaws continues to resist preventive and treatment measures and to impact on the quality of life of the patient. However, the past decade has witnessed improved awareness and understanding of this frustrating entity. The radiobiology of ORN is a complex of cellular death and cellular functional impairments from radiation energy transfers. The specific pathophysiologic sequence is radiation, followed by the development of hypovascular-hypocellular-hypoxic tissue. The result is a radiation-induced wound-healing defect. Trauma-induced or

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