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March 1989

Measurement of a Tissue Compliance Coefficient as an Index of Tissue Pressure: Results of a Dehydration Experiment

Author Affiliations

Oakland, Calif

Arch Otolaryngol Head Neck Surg. 1989;115(3):273. doi:10.1001/archotol.1989.01860270015002

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At the fall 1988 meeting of the American Academy of Facial Plastic and Reconstructive Surgery in Washington, DC, Rick Odland, MD, Minneapolis, presented the third in a series of studies that explore the hypothesis that edema and elevated tissue pressure contribute to skin flap necrosis. Dr Odland and his coresearcher, James I. Cohen, MD, report that direct measurement of interstitial tissue pressure has not been possible. They have devised a method of measuring tissue compliance, which is a correlate of tissue pressure.

Using a microinjector, which is designed to monitor pressure within the syringe and needle, tissue pressure at the needle tip is continuously recorded. A tissue compliance coefficient is calculated, based on interstitial pressure response to injection of 0.1 μL of saline. The authors attempted to confirm that this method is a true measure of tissue pressure by two using the following methods.

  1. 1. Tissue compliance coefficient was

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