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March 1989

Botulinum Toxin Therapy for Spasmodic Dysphonia Recurring After Nerve Resection

Arch Otolaryngol Head Neck Surg. 1989;115(3):275. doi:10.1001/archotol.1989.01860270017008

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Christy Ludlow at the National Institutes of Health, Bethesda, Md, recently reported the use of Clostridium botulinum toxin for treatment of patients with spasmodic dysphonia who had failure of previous recurrent laryngeal nerve section. Her report, presented at the American Academy of Otolaryngology–Head and Neck Surgery meeting in Washington, DC, involved the evaluation of five patients who had previous nerve section and had recurrence of their spasmodic dysphonic symptoms. Her evaluation utilized voice spectrography and electromyographic studies. She found hypertonic activity on the operated-on and supposedly denervated side. These patients were injected with C botulinum toxin in the operated-on cord. In addition, two patients needed additional injections in the unoperated-on cord. All the patients had significant reduction in symptoms. After injection, the hypertonic activity was reduced in the injected and uninjected muscles.

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