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April 1989

Three Cases of Wegener's Granulomatosis Treated With an Antimicrobial Agent

Author Affiliations

From the Department of Otolaryngology, Kagoshima (Japan) University School of Medicine (Drs Fukuda, Uchizono, Matsuyama, and Ohyama); and the Department of Internal Medicine, Tokyo University Institute of Medical Science (Drs Yuasa and Shimada).

Arch Otolaryngol Head Neck Surg. 1989;115(4):515-518. doi:10.1001/archotol.1989.01860280113028

• Sulfamethoxazole-trimethoprim, an antimicrobial agent, was used to treat three cases of cytotoxic agent-resistant Wegener's granulomatosis; one case was refractory to a regimen consisting of azathioprine and prednisolone, and in another two cases the therapy was insufficient to control the disease. By the introduction of sulfamethoxazole-trimethoprim, which has an advantage of fewer side effects compared with the conventional agents, into the regimen, the disease condition was markedly improved in all cases within four months. Sulfamethoxazole-trimethoprim is thus considered as one of the most promising drugs to treat, especially, cytotoxic agent-resistant Wegener's granulomatosis. The possible underlying mechanism of the effect of sulfamethoxazole-trimethoprim is also described.

(Arch Otolaryngol Head Neck Surg 1989;115:515-518)

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