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July 1989

Human Papillomavirus: Its Significance in Tumor Margins

Author Affiliations

University of Texas, Galveston

Arch Otolaryngol Head Neck Surg. 1989;115(7):775. doi:10.1001/archotol.1989.01860310013001

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At the 92nd annual meeting of the American Academy of Otolaryngology–Head and Neck Surgery in Washington, DC, Abby E. Gross, MD, and coworkers, Albert Einstein Medical College, New York, NY, presented their investigation concerning the significance of human papillomavirus (HPV) in tumor margins in squamous cell carcinoma of the upper aerodigestive tract. Previous studies of tissue adjacent to benign lesions induced by the presence of HPV types 6 and 11 suggested viral involvement beyond the gross lesion with presence of HPV DNA. Verrucous carcinoma, an exophytic variant of squamous cell carcinoma, has been noted to contain the HPV DNA protein when examined, and to exhibit the histologic phenomenon of koilocytosis. Koilocytosis was defined as the cellular characteristic of an enlarged hyperchromatic nucleus with perinuclear halos. This has been considered by some pathologists as pathognomonic in squamous cell carcinoma of the uterine cervix. The authors reminded the audience that HPV, a

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