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August 1989

A Factor in Food That Impairs the Endolymphatic Sac Sodium- and Potassium-Dependent Adenosinetriphosphatase In Vivo

Author Affiliations

San Diego, Calif

Arch Otolaryngol Head Neck Surg. 1989;115(8):903. doi:10.1001/archotol.1989.01860320013002

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At the meeting of the Western Section of The Triological Society in January, Phyllis A. Wackym, MD, Los Angeles, Calif, and collaborators, Uppsala, Sweden, reported a study demonstrating a food factor that impaired sodium- and potassium-dependent adenosine triphosphatase (ATPase) in mice. These investigators reported that Meniere's disease is known to be caused by expansion of the endolymphatic space. The exact mechanism is not known, but impairment of absorption of endolymph is commonly thought to be a factor. The importance of the endolymphatic sac in resorption of endolymph is well known. Electron microscopic studies at the House Ear Institute, Los Angeles, Calif, show that the intraosseous endolymphatic sac is made of saclike spaces and tubules. Two of the theoretical mechanisms of endolymph outflow that have been postulated are type I, lateral intracellular spaces of the sac (LISS) absorb endolymph; and type II, active transcellular ion exchange, dependent on sodium-and potassium-dependent ATPase,

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