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October 1989

Fibrosarcoma of the Mandible Following Supravoltage Irradiation: Report of a Case

Author Affiliations

From the Ear, Nose, and Throat (Drs Moloy and Kowal) and Oral Surgery (Dr Siegel) Sections, Veterans Administration Medical Center, Long Beach, Calif, and the Division of Otolaryngology–Head and Neck Surgery, University of California, Irvine (Drs Moloy and Kowal). Dr Moloy is presently with the Albany (NY) Medical Center.

Arch Otolaryngol Head Neck Surg. 1989;115(10):1250-1252. doi:10.1001/archotol.1989.01860340104028

• Supravoltage irradiation is commonly thought not to be carcinogenic. Several recent studies question this concept, as does our case report. A 50-year-old woman with stage 1 squamous carcinoma of the left side of the tongue was treated in 1973 with 73 Gy of supravoltage irradiation. Twelve years later a painful, ulcerated lesion that eventually was shown to be fibrosarcoma developed in the contralateral mandible. The fibrosarcoma in this case fulfills all criteria for diagnosing radiation-induced neoplasia and demonstrates that supravoltage irradiation, like other forms of irradiation, can cause malignancy. The occasional occurrence of sarcoma should be recalled during follow-up of patients treated with supravoltage radiation. Similarly, the possibility of radiation-induced tumors should be considered in planning treatment for younger patients with tumors that can be treated equally well by surgery or irradiation.

(Arch Otolaryngol Head Neck Surg. 1989;115:1250-1252)

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