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February 1990

Intraoperative Radiotherapy of Head and Neck Cancer

Author Affiliations

From the Department of Otolaryngology—Head and Neck Surgery, Naval Hospital, Portsmouth, Va (Dr Freeman); Head and Neck Surgery Associates, Indianapolis, Ind (Drs Hamaker and Singer); and the Department of Radiation Therapy, Methodist Hospital of Indiana Inc, Indianapolis (Drs Pugh, Garrett, and Ross).

Arch Otolaryngol Head Neck Surg. 1990;116(2):165-168. doi:10.1001/archotol.1990.01870020041011

• Intraoperative radiotherapy (IORT) was developed as an adjuvant to surgery and external beam radiation for aggressive, extensive, or recurrent cancers of the head and neck. This report reviews the indications, technique, response, and complications of IORT. From May 1982 to May 1988, 104 patients received 15 to 20 Gy of radiation delivered through a Lucite cone to areas of high risk of recurrence following resection and prior to closure. The indications for treatment were (1) aggressive primary or recurrent cancer; (2) disease fixed to deep muscle, carotid, or bone; or (3) close margins in an effort to preserve vital structures or function. The IORT was effective in preventing local recurrence in 14 (40%) of 35 patients with 2-year follow-up of squamous cell carcinoma. The complication rate was acceptable. Intraoperative radiotherapy appears to be a safe and beneficial adjunctive therapy for cancers that historically have extremely dismal prognoses.

(Arch Otolaryngol Head Neck Surg. 1990;116:165-168)

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