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September 1990

Receptors in Acoustic Neuroma-Reply

Arch Otolaryngol Head Neck Surg. 1990;116(9):1092. doi:10.1001/archotol.1990.01870090108022

In Reply.—Thank you for the opportunity to answer Dr Monsell's letter. Dr Monsell argues that the immunohistochemical (ERICA) method used by us1 is less sensitive than the one used by Monsell and Wiet.2 We do not quite understand which method actually was used by Monsell and Wiet. If the method used was a radioligand assay, the dextran-coated charcoal method with Scatchard plot analysis, there is nothing in the literature indicating that this method is more sensitive than the ERICA assay. As an example, hormone receptors have never been detected biochemically in benign and normal breast tissue. However, such tissue does have cells, although often few, that react positively in immunohistochemical assays.3 On the other hand, if the method used was an enzyme immunoassay, this method is found to be more sensitive than the dextran-coated charcoal assay,4 but again, there is nothing in the literature indicating