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October 1990

Laser Photodynamic Therapy for Papilloma Viral Lesions

Author Affiliations

From the Department of Surgery, University Hospital of Maastricht (the Netherlands) (Dr Go); the Department of Medicine and Surgery (Dr Straight and Mr Reed), Veterans Affairs Medical Center University of Utah Laser Institute, Salt Lake City; and the Department of Otolaryngology, University of Arkansas Medical College, Little Rock (Dr Waner).

Arch Otolaryngol Head Neck Surg. 1990;116(10):1177-1180. doi:10.1001/archotol.1990.01870100071015

• Photodynamic therapy was tested for its therapeutic efficacy in eradicating rabbit papilloma warts. The wild-type viral warts suspension was used to induce treatable papilloma warts in the cutaneous tissue of Dutch Belted rabbits. The photosensitizing agents used intravenously were Photofrin II at 10 mg/kg of body weight and Chlorin e6 monoethylene diamine monohydrochloric acid (Chlorin e6 med HCl) at 1 mg/kg of body weight. The lasers used were an argon-dye laser at 628 and 655 nm and a gold vapor laser at 628 nm. The irradiances of 25 to 180 mW/cm2 were applied topically with an end-on lens optical fiber with total radiant doses of 7.5 to 54 J/cm2. Photofrin II and the argon-dye laser at the highest light dosage (54 J/cm2) and Chlorin e6 monoethylene diamine monohydrochloride administered 2 hours before argon-dye laser irradiation at 655 nm at the highest light dosage (54 J/cm2) produced wart regression. Total wart regression without recurrence was achieved with Photofrin II and the gold vapor laser at all light dosages. The difference observed between the argon-dye laser and the gold vapor laser might be explained by the pulsed nature of the gold vapor laser, with its high-peak powers, some 5000 × the average measured light dose. In this model, the smaller, less cornified lesions were more effectively treated with photodynamic therapy.

(Arch Otolaryngol Head Neck Surg. 1990;116:1177-1180)