[Skip to Navigation]
November 1990

Photodynamic Therapy With Chloroaluminum-Sulfonated Phthalocyanine

Author Affiliations

From the Department of Head and Neck Surgery (Dr Stern) and the Laser Biology Research Laboratory (Drs Thomsen and Jacques and Ms Small), M. D. Anderson Cancer Center, Houston, Tex.

Arch Otolaryngol Head Neck Surg. 1990;116(11):1259-1266. doi:10.1001/archotol.1990.01870110031002

• To study the vascular effects of a new photosensitizing agent independent of the influence of tumor growth, a cutaneous wound model was used. Six-week-old Harlan-Sprague-Dawley "Fuzzy" rats were surgically wounded in a standard fashion. The animals were then divided into three groups: the first group received chloroaluminum - sulfonated phthalocyanine only, the second group was treated with light only, and a third group was treated with both chloroaluminum-sulfonated phthalocyanine and light. Photodynamic therapy with chloroaluminum-sulfonated phthalocyanine had a direct effect on the neovasculature of a healing wound. The vasodilatation that was seen in the wound neovasculature that occurred 12 hours after the completion of chloroaluminum-sulfonated phthalocyanine—photodynamic therapy may have indicated a therapeutic "window" at which other therapies can be employed to improve clinical efficacy.

(Arch Otolaryngol Head Neck Surg. 1990;116:1259-1266)

Add or change institution