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January 1991

Tumor-Infiltrating Lymphocytes in Squamous Cell Carcinoma of the Head and Neck

Author Affiliations

Norfolk, Va

Arch Otolaryngol Head Neck Surg. 1991;117(1):17. doi:10.1001/archotol.1991.01870130023002

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At the annual meeting of the American Academy of Otolaryngology–Head and Neck Surgery, San Diego, Calif, September 1990, David E. Eibling et al, San Antonio, Tex, presented their work with tumor-infiltrating lymphocytes in locally advanced squamous cell carcinoma of the head and neck.

Twenty-two patients with advanced squamous cell carcinoma of the head and neck were studied for a minimum of 30 months. Correlation between in situ characteristics of tumor-infiltrating lymphocytes and recurrent disease was investigated. At the time of surgery, tumor specimens were collected, snap frozen, and stained with immunoperoxidase. Monoclonal antibodies were used for identification and classification. A variety of head and neck sites were included in the study. Lymphocytes with the CD4+ marker were predominant in the parenchyma of tumors.

Twelve patients (55% ) developed recurrent disease from 4 to 18 months after therapy. There was a significant difference in recurrence rates between patients having greater than 20

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