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June 1991

Inner Ear Damage Secondary to Diabetes Mellitus: I. Changes in Adolescent SHR/N-cp Rats

Author Affiliations

From the Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill (Drs Triana, Suits, Prazma, and Pillsbury, and Messrs Garrison and Brechtelsbauer); and the Beltsville (Md) Human Nutrition Research Center, Agriculture Research Service, US Department of Agriculture (Dr Michaelis).

Arch Otolaryngol Head Neck Surg. 1991;117(6):635-640. doi:10.1001/archotol.1991.01870180071014

• The association between diabetes mellitus and hearing impairment has been debated in many previous studies. The spontaneous hypertensive/NIH-corpulent (SHR/N-cp) rat has been shown to be a unique genetic model for non—insulin-dependent diabetes mellitus. Seventeen diabetic and 17 control young male rats were divided into groups according to diet and phenotype. The rats were fed either 54% of sucrose or 54% starch diets for 3.5 months and killed at 5 months. The cochleas were fixed, decalcified, dissected, and stained for hair cell counting. A significant loss of outer hair cells was noted in the diabetic obese (SHR/N-cp) animals when compared with the control obese (LA/N-cp) animals in every group. Although no significant difference was noted between the diabetic obese (SHR/N-cp) animals receiving the starch and sugar diets, the diabetic obese (SHR/N-cp) animals were more severely affected than the nondiabetic lean (SHR/N-cp) rats.

(Arch Otolaryngol Head Neck Surg. 1991; 117:635-640)

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